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Further information and requests for resources and reagents should be directed to and will be fulfilled by the lead contact, peter ly (peter.ly@utsouthwestern.edu). The ly laboratory seeks to understand how cells maintain genome stability and how dysregulation of these pathways impact human health and disease, particularly in the context of cancer development. Molecular lassos that herd pulverized micronuclear chromosomes chromosome segregation errors generate a diverse spectrum of simple and complex genomic rearrangements

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Cancer cells frequently harbor complex genomes that are characterized by numerical and structural chromosomal abnormalities 由德克萨斯大学西南医学中心的研究人员领导的一项发表在《Cell》杂志上的研究，为我们理解癌症生物学中的关键机制问题带来了新的突破，也为避免癌症耐药性提供了可能的新策略。 Our laboratory investigates the cellular and molecular mechanisms that shape the chaotic mutational landscape of cancer genomes.

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他们的研究结果发表在《Cell》杂志上，解释了一些肿瘤中的染色体如何进行大规模重排，并可能导致避免癌症耐药性的新策略。

Ly returned to ut southwestern to establish his independent group in the department of pathology, and, in 2025, dr He holds secondary appointments in cell biology, pediatrics, and the harold c Simmons comprehensive cancer center at ut southwestern.